NiteCue. Pre-Void Detection for Bedwetting

A smart wearable belt designed to identify the pre-void window and alert before wetting begins.

NiteCue is building a wearable platform designed to identify pre-void signals and alert before wetting begins. Built by IA21 BioSystems. Pre-void detection for bedwetting. Dry nights, confident mornings.

The Challenge: Every family deserves a peaceful night

Bedwetting disrupts more than sleep. It affects a child's confidence, creates nightly anxiety, and adds stress to the whole family's routine.

  • 7.7% global prevalence in children and adolescents
  • 250 million children and adults affected
  • 50% relapse rate with medication
  • 30% drop-off rate with traditional alarms

Today's solutions are reactive

  • Traditional alarms react after wetting has already started, with high drop-off rates.
  • Medications offer symptom relief but may come with side effects and relapse.
  • Absorbent products manage the symptom without addressing prevention.

What if a wearable could identify pre-void signals and alert before wetting begins?

PreVoid ML Technology: From signal to prediction

PreVoid ML is the biosensing and machine-learning engine being developed inside NiteCue. Multi-sensor analysis is designed to identify physiological patterns associated with bladder filling and the pre-void window, analyzed in real time by an on-device model. Four layers of intelligence are designed to work together to support an alert before wetting begins. No ionizing radiation. Low-power wearable electronics only.

  1. Sense — Physiological signal capture. A gentle sensor array is designed to capture non-invasive physiological signals through the skin.
  2. Fuse — Multi-sensor noise reduction. Multiple data streams are fused in real time, filtering out noise and false triggers.
  3. Learn — Personalized pattern modeling. On-device learning is designed to build a personalized model from each child's overnight physiological patterns.
  4. Predict — Pre-void window alert (intended). A gentle vibration is intended to alert before wetting begins. Reliability of this alert is subject to planned clinical validation.

The Intended NiteCue Experience

The final product experience is subject to successful feasibility testing, product development and clinical validation.

  1. Wear & Start. The system is being designed for a simple nightly setup: a comfortable, low-profile belt worn at bedtime.
  2. Identify & Alert. Following successful feasibility and validation, the intended system will be designed to deliver a personalized alert before a wetting event.
  3. Wake & Go. The intended experience: an earlier wake so the child can reach the bathroom before a full wetting event.
  4. Track & Train. The planned companion experience may provide parents with a private nightly summary. Over time, the intended machine-learning model will be designed to learn each child's individual physiological patterns.

Benefits: Built around your family's needs

  • Earlier alerts. Designed to identify pre-void signals and alert before wetting begins, not after.
  • Confidence & calm. Fewer anxious nights and more confident mornings, building your child's self-esteem.
  • Better sleep flow. Less disruption means better rest for your child and the whole family.
  • Discreet nightly routine. Designed to blend into bedtime without drawing attention.
  • Progress parents can see. Track dry-night progress over time and celebrate milestones together.
  • Designed for home use. Simple, comfortable, and made for everyday life. No clinical setting required.

For Parents: Built around your family, not a lab

Bedwetting is exhausting for parents and confusing for kids. NiteCue is designed to identify pre-void signals and gently wake your child in time to get to the bathroom, helping reduce wet nights over time. One short wake-up, instead of wet sheets, a full change, and a restart at 3am.

  • Fewer wet sheets and less laundry in the middle of the night.
  • Confident mornings: your child wakes up dry, ready for school, sleepovers, and camp.
  • Real progress over time that the whole family can see and track.

About Bedwetting (Nocturnal Enuresis)

Nocturnal enuresis affects 250 million children and adults worldwide. Current solutions are reactive: they alert only after wetting has already happened. NiteCue is designed to identify pre-void signals and alert before wetting begins, helping reduce wet nights over time. NiteCue is being developed for children aged roughly 5 and up, the age range where bedwetting starts to affect confidence, sleepovers, and family routines.

Market opportunity

NiteCue targets a large global condition affecting 250 million children and adults, with an opportunity to build a new category beyond reactive alarms and medication.

Starting with bedwetting. Building a broader bladder intelligence platform

NiteCue is focused first on pediatric nocturnal enuresis. The underlying sensing architecture, personalized prediction engine and growing physiological dataset may be adapted over time across additional urinary-care markets. Future applications are potential adaptations, subject to separate research, development and clinical validation, not validated across every population.

  1. 01. Pediatric nocturnal enuresis — Entry market.
  2. 02. Adult nighttime incontinence and nocturia — Potential future adaptation.
  3. 03. Geriatric and institutional continence care — Potential future adaptation.
  4. 04. Neurogenic bladder and digital urology — Potential future adaptation.
  5. 05. Daytime continence support — Potential future adaptation.
  6. 06. Nighttime toilet training — Potential future consumer extension.

Founder Story

"I experienced bedwetting as a child. Decades later, I watched my own son go through the same thing, with the same outdated solutions. I knew it was time for something different." — Itay Avni, Founder & CEO.

Team

Core team

  • Itay Avni — Founder & CEO. Biomedical engineer and commercial leader with nearly 20 years across Philips, Johnson & Johnson, Edwards Lifesciences and international medical-device ventures.
  • Yoav Aminov — Algorithm Development. Biomedical engineering with deep expertise in machine learning and signal processing for health applications.
  • Nohayo Ltd — Hardware Partner. Building advanced wearable and digital health hardware with proven manufacturing expertise.

Advisory Board

  • Prof. Konstantinos Kamperis — Clinical Advisor, Pediatric Nephrology. Professor, Pediatric Nephrology, Aarhus University Hospital. Past President of ICCS (2022–2024).
  • Dr. Anka Nieuwhof Leppink — Clinical Advisor, Urotherapy. Head of Urotherapy, Wilhelmina Children's Hospital. ICCS Board Member, ESPU Research Committee.
  • Dr. Reut Yalon, PhD — Product & Strategy Advisor. Commercial and product strategy leader. VP, Category Leader Azurion Eye at Philips; former CPO at Aidoc. Led development and commercialization of dozens of FDA-cleared clinical AI products. PhD, Weizmann Institute of Science.

Backed by

NiteCue is backed by the Israel Innovation Authority, which selected the project for its Tnufa program, a national initiative supporting early-stage deep-tech ventures with strong technological and market potential.

Validation: Proving the signal before building the product

NiteCue is at the proof of concept stage. The current feasibility study is designed to test whether consistent, non-invasive physiological patterns can be detected before a wetting event. We haven't opened pre-orders yet; families on our waitlist will be the first to know about pilots, early access, and availability.

Feasibility objectives

  1. Build a labeled overnight dataset across a representative cohort of children with nocturnal enuresis.
  2. Identify the most informative sensor set for detecting pre-void physiological patterns.
  3. Evaluate whether consistent, learnable patterns exist ahead of a wetting event.
  4. Determine clear go/no-go criteria for advancing to a predictive prototype and a formal clinical validation study.

Safety

NiteCue is being designed as a non-invasive, externally worn system. Materials, skin-contact safety, comfort and age suitability will be assessed throughout product development and validation.

Vision

Every child deserves to wake up confident. NiteCue is building a wearable platform designed to identify pre-void signals and alert before wetting begins.

Frequently Asked Questions

Is NiteCue safe for my child?

NiteCue is being designed as a non-invasive, externally worn system. Materials, skin-contact safety, comfort and age suitability will be assessed throughout product development and validation.

What age is it for?

NiteCue is being developed for children aged roughly 5 and up. Exact age suitability is being validated as part of our clinical work.

When can I get one?

NiteCue is currently in active development. Pre-orders are not open. Families on our waitlist will be the first to know about pilots, early access, and availability.

What is NiteCue?

A wearable platform being developed to identify physiological patterns associated with the pre-void window during sleep and support an alert before wetting begins.

How does the alert work?

Multi-sensor analysis is designed to identify physiological signals associated with bladder filling. When the planned prediction model identifies a likely pre-void window, the device is intended to deliver a gentle vibration or sound alert.

What is the market opportunity?

NiteCue targets a large global condition affecting 250 million children and adults, with an opportunity to build a new category beyond reactive alarms and medication.

Who backs NiteCue?

NiteCue is backed by the Israel Innovation Authority through its Tnufa program.

Company & Contact

NiteCue is developed by IA21 BioSystems, founded by Itay Avni. Contact: itay.avni@nitecue.ai. Website: nitecue.ai.